THE ROLE OF PLANT EXTRACTS IN THE REPAIR OF Rattus Norvegicus MANDIBULAR ALVEOLAR BONE IN A PERIODONTITIS MODEL

The evaluated herbs plants (α-Mangostin, usnic acid, Piper betle L, and Daemonorops draco) have potency in the
alveolar bone repair of mandibular on the periodontitis modeling. Its herbs were evaluated with the flavonoid and
phenolic, and ionic values identified by a multi-tester meter. Mol-inspiration software was used to calculate the
miLogP value of -mangostin and usnic acid. The evaluation of alveolar bone repair is based on H and E staining
profiles of osteoblasts and osteoclasts. The α-Mangostin and Piper beetle L had higher total flavonoid and phenolic
concentrations than usnic acid and Daemonorops draco. Based on the miLogP value, usnic acid has better absorption
than α-mangostin. The ionic amounts of dissolved Oxygen, conductivity, and total dissolved solids have correlated
with osteoblast and osteoclast expression in the bone repair process. The herbs extract can increase the stimulation to
produce osteoclast and stability in 7 and 14 days. The ionic values, flavonoids, and phenolic totals of herbs affect the
mandibular alveolar bone repair, which is marked to increase the new bone formation (osteoblast) and bone resorption
(osteoclast).

Keywords: Alveolar Bone, Plant Herbs, Periodontitis, Osteoblast, and Osteoclast.