Role of Ziziphus mauritiana Lam. on Oral Candidiasis and its Relation to the Antibody Response, Blood Electrolyte, and Liver Profil

Candida albicans is the primary agent in the pathogenesis of oral candidiasis involving liver
metabolism, immune cells, and blood electrolytes. Ziziphus mauritiana Lam. was reported as an
antifungal and an immunostimulator in the regulation of blood physiology.
The aim of this study is to evaluate the effect of Z. mauritiana Lam. on oral mucosal healing after
infection with C. albicans, which further affects the immune response, blood electrolytes, and liver
defense system. The mucosa, immune cells, and liver samples of 20 mice (Rattus novergicus) were
examined via H&E staining. The blood electrolytes were investigated using the Caretium X931FT
electrolyte analyzer. Z. mauritiana Lam. was extracted with ethanol, and its compounds were
analyzed with GCMS. Meanwhile, the bioactivity was analyzed using the Molinspiration
Cheminformatics software. Z. mauritiana Lam. can repair and prevent damage to epithelial cells,
fibroblasts, and keratinization in the mucosa, as characterized by the increased blood immune cell
response, blood electrolyte stability, and liver cell function.
The experimental period was 7 and 14 days. At the same time, potassium increased in contrast
to the average value. Z. mauritiana Lam. presented high biological activity on all compounds (>.00),
especially GPCR ligands, nuclear receptor ligands, protease inhibitors, and enzyme inhibitors. This
ligand inhibits pathogen interaction with host cells, subsequently helping with the healing process
and damage of C. albicans cells. Z. mauritiana Lam. may improve the healing of oral mucosal
infections, reduce the frequency of C. albicans, and maintain immune cell response, liver
metabolism, and blood electrolyte balance as mediated by the biological activity.

Keywords: Candida albicans, cell immune, liver, mucosal oral, Ziziphus mauritiana Lam.