The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model

Citra Lestari, Citra Lestari and Eryati Darwin, Eryati Darwin and Deddi Prima Putra, Deddi Prima Putra and Netti Suharti, Netti Suharti (2021) The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model. Journal of Pharmacy and Pharmacognosy Research, 9 (5). pp. 609-618. ISSN 0719-4250

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Abstract

Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The α-mangostin has shown role-playing in the bone remodeling process.
Aims: To evaluate the potential of α-mangostin induce the TGFβ1 titer associated with the increased mandibular bone volume on the alveolar bone remodeling of periodontitis of Rattus novergicus.
Methods: The α-mangostin used to the single administration dosage on the rat periodontitis model on the 7 and 14 days. TGF-β1 titer tested by enzyme-linked immunosorbent assay, while the X-Ray Micro-CT/Micro Computed Tomography examined the volume's development of the mandibular bone.
Results: At the 7 days, 0.5 and 1% of α-mangostin had a better effect to increase the bone volume, and TGF-β1 titer has linearity of bone development at concentrations of 0.5 to 2%. At 14 days, 1 and 2% of α-mangostin exhibited a better effect on inducing an increase in mandibular bone volume and TGF-β1 titer. The linearity of both occurs at concentrations of 0.5 to 1%. The Micro-CT of the mandibular bone showed callus or new bone formation at the edge of each treatment group's lesion as an indicator of bone remodeling.
Conclusions: α-Mangostin induced an increase in the TGF-β1 titer, which was in line with the rise in the volume of the mandibular bone of Rattus novergicus.

Keywords: bone volume; mandibular; α-mangostin; periodontitis; TGF-β1.

Item Type: Article
Subjects: R Medicine > RK Dentistry
Divisions: Fakultas Kedokteran Gigi > Program Studi Kedokteran Gigi
Depositing User: Dr. drg. Citra Lestari, MDSc, Sp.Perio Citra
Date Deposited: 21 Feb 2023 12:50
Last Modified: 21 Feb 2023 12:50
URI: http://repository.unbrah.ac.id/id/eprint/234

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