The Association of Serum Glial Fibrillary Acidic Protein Level, and Outcome of Traumatic Brain Injury (doc)

Dian Ayu Hamama Pitra, Dian Ayu Hamama Pitra and Yuliarni Syafrita, Syafrita Y and Ellyza Nasrul, Nasrul E and Rika Susanti, Susanti R and Rauza Sukma Rita, Sukma Rita R The Association of Serum Glial Fibrillary Acidic Protein Level, and Outcome of Traumatic Brain Injury (doc). Journal of Positive Psychology & Wellbeing.

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Abstract

Currently, the initial evaluation of patients with traumatic brain injury depends on examining the Glasgow coma scale (GCS) and imaging. But both modalities have limitations. Several studies have focused on biomarkers in traumatic brain injury because biomarkers are easily measured. A
biomarker often used to assess the outcome and severity of traumatic brain injury is serum glial fibrillary acidic protein (GFAP). This study was aimed to find the association between serum GFAP levels with the outcome of
traumatic brain injury. In 60 subjects with TBI recruited, serum, taken at hospital admission, was analyzed for GFAP. Data collected were the severity of injury based on the GCS. One month later, the outcome was assessed based on the Glasgow outcome scale (GOS). Besides GFAP, some variables
that affect the outcome, such as age, pupillary reaction, therapy, hypotension, were also analyzed. There was a highly significant association between serum GFAP levels on admission with outcome one month after onset (p <0.001). Multivariable analysis showed that GFAP was the strongest in predicting unfavourable outcomes. The higher serum GFAP
contribute to unfavourable outcomes of traumatic brain injury.
Keywords: Biomarker, traumatic brain injury, glial fibrillary acidic protein, outcome

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Amd Regina Andina
Date Deposited: 25 Nov 2022 03:58
Last Modified: 25 Nov 2022 03:58
URI: http://repository.unbrah.ac.id/id/eprint/186

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