Comparative Effectiveness of Rocuronium and Succinylcholine in Rapid Sequence Intubation: A Systematic Review

Background: Rocuroniumand succinylcholine (suxamethonium) areneuromuscular blocking agents that may be considered for use in rapid sequence intubation (RSI). Rapid sequence intubation is an airway management technique that facilitates swift induction and muscle relaxation, recognized as the most expedient and successful method for securing the airway in emergencies. Therefore, the selection of an ideal muscle relaxant is essential in this setting.Objective:This systematic review aims to evaluate and analyze the available evidence comparing the effectiveness of the muscle relaxants rocuronium and succinylcholine in patients undergoing rapid sequence intubation. Based on the search and screening process, four studies were included, which met the inclusion criteria and were analyzed further.Methods:The literature search was conducted through electronic databases using specific keywords in published journal databases, including ScienceDirect, PubMed, and GoogleScholar.The search terms used weremusclerelaxant,rocuronium,succinylcholine, andrapid sequence intubation. Based on the search and screening process, four articles met the inclusion criteria and were analyzed further. These articles were evaluated to determine their relevance to the objectives of this systematic review. Data analysis was performed to identifythe main findings regarding the comparison of the effectiveness of rocuronium and succinylcholine as muscle relaxants in patients undergoing rapid sequence intubation.Results:This systematic review demonstrates that succinylcholine and rocuronium have comparable clinical quality and effectiveness. Analysis of the four articles that met the inclusion criteria revealed that both succinylcholine and rocuronium provide good and comparable effectiveness. These findings indicate that succinylcholine and rocuronium are appropriate muscle relaxants for rapid sequence intubation when used according to their respective indications and contraindications.Conclusion:Based on the findings of this systematic review, it can be concluded that both succinylcholine and rocuronium can be used effectively for tracheal intubation, with acceptable intubation conditions in both groups. However, the use of succinylcholine and rocuronium should take into account patient-specific indications and contraindications